%0 Journal Article %A van Heyningen, W. E. %A Mellanby, Jane %T The Effect of Cerebroside and Other Lipids on the Fixation of Tetanus Toxin by Gangliosides %D 1968 %J Microbiology, %V 52 %N 3 %P 447-454 %@ 1465-2080 %R https://doi.org/10.1099/00221287-52-3-447 %I Microbiology Society, %X SUMMARY: Water-insoluble complexes of ganglioside with cerebroside fixed tetanus toxin at low concentrations (a few LD 50/ml.) of toxin. A complex containing 25% ganglioside with cerebroside was 50 times better at fixing toxin than complexes containing either 2% or 50% ganglioside. A complex containing 25% of a mixture of the gangliosides Giii and Giv was 12 times better at fixing toxin than a similar complex with gangliosides Gi and GII. Complexes of ganglioside with sphingomyelin and lecithin fixed toxin to a slight extent, while complexes with tripalmitin and cholesterol did not fix toxin. The complex of cerebroside and ganglioside, containing 25% ganglioside, did not fix strychnine, serotonin, botulinum toxin or plasma albumin. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-52-3-447