1887

Abstract

SUMMARY

The effects of two drugs (chloramphenicol, actinomycin D) which inhibit protein synthesis on the nucleus of the dinoflagellate were examined. Chloramphenicol had no effect on the morphology of the nucleus but caused a diminution of cytoplasmic protein and a suppression of growth; did not completely suppress mitosis. Treatment with actinomycin D resulted in the loss of chromosomal arrangement within the nucleus, the fraying of the edges of the nucleus and the loss of the nuclear ‘band’, and suppressed division. The results are thought to support the hypotheses that the matrix functions in maintaining nuclear morphology and that the ‘band’ is necessary for mitosis.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-50-2-281
1968-02-01
2021-10-20
Loading full text...

Full text loading...

/deliver/fulltext/micro/50/2/mic-50-2-281.html?itemId=/content/journal/micro/10.1099/00221287-50-2-281&mimeType=html&fmt=ahah

References

  1. Chunosoff L., Hirshfield H. I. 1967; Nuclear structure and mitosis in the dinoflagellate Gonyaulax monilata . J. Protozool 14:157
    [Google Scholar]
  2. Dodge J. D. 1963; The nucleus and nuclear division in the Dinophyceae. Arch. Protistenk 106:442
    [Google Scholar]
  3. Dodge J. D. 1964; Nuclear division in the dinoflagellate Gonyaulax tamarensis . J. gen. Microbiol 96:269
    [Google Scholar]
  4. Goldberg I. H., Rabinowitz M. 1962; Actinomycin D inhibition of deoxyribonucleic acid-dependent synthesis of ribonucleic acid. Science, N. Y 136:315
    [Google Scholar]
  5. Honig G., Rabinovitz M. 1966; Actinomycin D: inhibition of protein synthesis unrelated to effect on template RNA synthesis. Science, N. Y 149:1504
    [Google Scholar]
  6. Reich E. A., Franklin R. M., Shatkin A. J., Tatum E. L. 1962; Action of actinomycin D on animal cells and viruses. Proc. natn. Acad. SciU.S.A 481238
    [Google Scholar]
  7. Rendi R., Ochoa S. 1962; Effect of chloramphenicol on protein synthesis in cell-free preparations of Escherichia coli . J. biol. Chem 237:3711
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-50-2-281
Loading
/content/journal/micro/10.1099/00221287-50-2-281
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error