SUMMARY: The changes in fowl-plague infected tissue cultures have been investigated by the phase-contrast, and electron microscopes. The nucleolus of infected cells first increased in size and then became granular and highly refractile, finally disintegrating into fragments about 64 hr. after infection. After 36– 48 hr., when the inclusions were already developed, filaments were found, usually in bundles, possibly having escaped from the nucleus into the cytoplasm; a few filaments showed segmentation into spherical bodies and shorter filaments. A possible life cycle is suggested for the virus: first, penetration of the nucleus and growth within it, then extension into the cytoplasm in a filamentous form, and eventual segmentation of some of the filaments into elementary bodies.


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