SUMMARY: Cephaloridine has a broad spectrum of antibacterial activity, but certain Gram-negative organisms (e.g. ) are resistant by reason of their ability to destroy the antibiotic. Methicillin and cloxacillin do not inhibit Gram-negative organisms but are resistant to the βbT-lactamases which some strains produce and can protect cephaloridine from destruction by such enzymes. This protection effect towards cephaloridine has been demonstrated and on experimentally infected mice. In , a relatively small proportion of the penicillin exerted a maximal protecting effect towards cephalosporin and enhanced its bactericidal action against the Gram-negative organisms which produce °bT-lactamase. The clinical use of a combination of cloxacillin or methicillin with cephaloridine for the treatment of intractable systemic infections with °bT-lactamase-producing Gram-negative organisms is suggested, even though laboratory tests may show the organisms to be resistant to both cephaloridine and the penicillins when they are tested separately.


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