Effects of mutations in three independent proline suppressor loci were studied. Mutants of the locus were almost completely deficient in ornithine transcarbamylase activity and mutants of the locus produced ornithine δ-transaminase constitutively or semiconstitutively; this latter enzyme was strongly induced by arginine in the wild type. The and suppressor mutations were all recessive. Dominant and recessive mutants of the third suppressor locus, , showed higher activities of arginase and ornithine δ-transaminase than did the wild type. It is suggested that in all three cases the enzyme alterations caused by the suppressor mutations allow the synthesis of proline by an alternative route, replacing the blocked major pathway.


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