@article{mbs:/content/journal/micro/10.1099/00221287-47-1-111, author = "Harris, A. B.", title = "Inhibition of Growth and Nucleic Acid Synthesis in Iron-Deficient Mycobacterium smegmatis", journal= "Microbiology", year = "1967", volume = "47", number = "1", pages = "111-119", doi = "https://doi.org/10.1099/00221287-47-1-111", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-47-1-111", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "Surmmary Comparative studies of growth, yield of organism and synthesis of nucleic acids were made on a strain of Mycobacterium smegmatis grown with and without sufficient iron. Although the bacteria grew exponentially at the same rate in the iron-deficient medium as in the iron-replete medium, the content of RNA and DNA was lower in the iron-deficient bacteria. In the iron-deficient cultures, growth ceased abruptly after an exponential phase characterized by an inhibition of DNA synthesis. The pH value of the medium became increasingly acidic as iron-deficient growth proceeded.", }