SUMMARY: The exposure of tryptophan-requiring B/r WP2 to u.v.- and γ-irradiation (in either order) results in more revertants than would be expected if the two treatments were independent. The excess mutants (‘interaction mutants’) were produced in increasing number by increasing doses of u.v.-or γ-radiation. Evidence is presented that the interaction occurs post-irradiation. Although the excision-repair and mutation frequency decline systems for u.v. damage are not involved in the interaction itself (since a strain deficient in these systems, WP2 hcr, is no less efficient at producing interaction mutants than B/r WP2) the u.v. component involved in interaction is sensitive to one or both of these systems as is shown by the very much lower u.v. doses at which interaction occurs in WP2 hcr.


Article metrics loading...

Loading full text...

Full text loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error