SUMMARY: Griseofulvin induced various morphological abnormalities of the hyphae of and The growth-response curves obtained were unusual, and were due to the behaviour of the antibiotic. Repeated sub-cultivation of mycelium on Dox medium agar containing constant concentrations of griseofulvin produced trained mycelium which was however unstable. True adaptation of was obtained when faster growing sectors of mycelium were produced at the periphery of inhibited colonies. This adapted mycelium showed decreased morphological abnormality but still showed marked inhibition of growth. Chitin production, estimated as glucosamine, following growth in the presence of griseofulvin appeared to be stimulated in the walls of non-adapted mycelium, but remained at a relatively constant value in the walls of the adapted mycelium.


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