1887

Abstract

SUMMARY

penicillinase plasmid diploids of the type (. ip /.ipC), when constructed in strain 147, normally segregated one of the two parental genotypes at a frequency of about 1/5000 divisions, and recombinants were rare. In about 2% of the diploid clones, however, segregation occurred at a much higher frequency and in these clones both plasmids might be lost together. Examination of these ‘unstable’ diploids suggests that their two plasmids are associated to form a single structure, so that they are subsequently lost or transduced together. The ease of formation of associated diploids suggests that the penicillinase plasmids may be circular.

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/content/journal/micro/10.1099/00221287-46-1-85
1967-01-01
2022-01-21
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References

  1. Broda P. M. A., Beckwith J. R., Scaife J. 1964; The characterisation of a new type of F prime factor in Escherichia coli k12. Genet. Res 5:489
    [Google Scholar]
  2. Campbell A. M. 1962; Episomes. Adv. Genet 11:101
    [Google Scholar]
  3. Dyke K. G. H., Richmond M. H. 1967; The occurrence of various types of penicillinase plasmids among ‘hospital’ staphylococci. J. din. Path20
    [Google Scholar]
  4. Green S. 1962; Mercury sensitivity of staphylococci. J. clin. Path 15:249
    [Google Scholar]
  5. Jacob F., Brenner S., Cuzin F. 1963; On the regulation of DNA replication in bacteria. Cold Spring Harb. Symp. quant. Biol 28329
    [Google Scholar]
  6. Kogut K., Pollock M. R., Tridgell E. J. 1956; Purification of penicillin induced penicillinase of B. cereus nrrl 569; a comparison of its properties with those of a similarly purified penicillinase produced spontaneously by a constitutive mutant strain. Biochem. J 62:391
    [Google Scholar]
  7. Mitsuhasi S., Morimura M., Kono K., Oshima J. 1963; Elimination of drug resistance of Staphylococcus aureus by treatment with acriflavin. J. Bact 86:162
    [Google Scholar]
  8. Moore B. 1960; A new screen test and selective medium for the rapid detection of epidemic strains of S. aureus. Lancet ii:453
    [Google Scholar]
  9. Novick R. P. 1963; Analysis by transduction of mutations affecting penicillinase formation in S. aureus . J. gen. Microbiol 33:121
    [Google Scholar]
  10. Novick R. P. 1965; Co-transduction of a pair of Staphylococcus aureus penicillinase plasmids. Proc. 65th Annual Meeting American Soc. Microbiol., abstr. G 8928
    [Google Scholar]
  11. Novick R. P. 1966; The penicillinase plasmids of Staphylococcus aureus . Fedn Am. Socs. exp. Biol
    [Google Scholar]
  12. Novick R. P., Richmond M. H. 1965; Nature and interactions of the genetic elements governing penicillinase synthesis in S aureus . J. Bact 90:467
    [Google Scholar]
  13. Richmond M. H. 1965a; Penicillinase plasmids in S. aureus . Br. med. Bull 21:260
    [Google Scholar]
  14. Richmond M. H. 1965b; The dominance of the inducible state in strains of S. aureus containing two distinct penicillinase plasmids. J. Bact 90:370
    [Google Scholar]
  15. Richmond M. H. 1965c; Wild-type variants of exo-penicillinase from Staphylococcus aureus . Biochem. J 94:584
    [Google Scholar]
  16. Richmond M. H. 1966a; Some observations on the stability of penicillinase plasmids in S. aureus . Postepy Mikrobiologie 5:371
    [Google Scholar]
  17. Richmond M. H. 1966b; The genetic constitution of certain penicillinase ‘micro’ mutants in Staphylococcus aureus . J. gen. Microbiol 45:51
    [Google Scholar]
  18. Segalove M. 1947; The effect of penicillin on growth and toxin production by enterotoxic staphylococci. J. infect. Dis 81:228
    [Google Scholar]
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