RT Journal Article SR Electronic(1) A1 Ribbons, D. W.YR 1966 T1 Metabolism of o-Cresol by Pseudomonas aeruginosa strain T1 JF Microbiology, VO 44 IS 2 SP 221 OP 231 DO https://doi.org/10.1099/00221287-44-2-221 PB Microbiology Society, SN 1465-2080, AB SUMMARY: There is evidence that oxidation of o-cresol by Pseudomonas aeruginosa proceeds through 3-methylcatechol and 2-hydroxy-6-oxohepta-2,4-dienoic acid. 3-Methylcatechol has been characterized as a metabolite in growing cultures, and is oxidized by cells or cell extracts obtained from cultures grown on o-cresol but not by those grown on glucose. The rates of dissimilation of 2-hydroxy-6-oxohepta-2,4-dienoic acid are in excess of its rates of formation from 3-methylcatechol by extracts of cells. The catechol 2,3-oxygenase is formed in response to a variety of inducers and will cleave the ring of catechol and 4-methylcatechol also. The low specificity of the 2,3-oxygenase and earlier enzymic activities (hydroxylases), to both inducers and substrates, is discussed., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-44-2-221