SUMMARY: Anthranilic and -nitrobenzoic acids act as mutual inhibitors of both growth and substrate oxidation for and a flavobacterium which can utilize either substance as sole source of carbon, nitrogen and energy. Growth of the former bacterium on anthranilate induced, apparently simultaneously, both the transport system for anthranilate uptake and the enzymic mechanism necessary for its complete oxidation to CO and NH. Among the enzymes induced by anthranilate was the complete sequence that oxidizes catechol to β-oxoadipate; this was absent from organisms grown in fumarate or glucose media. The properties of the first enzyme in this sequence, a catechol-1, 2-oxygenase, differ in several features from those of the same enzyme induced in this bacterium by growth on -nitrobenzoic acid.


Article metrics loading...

Loading full text...

Full text loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error