SUMMARY: strain 52/152 produced compounds of the cycloheximide series and fungicidin. On the contrary its mutant strain 54/465 did not produce any compound of the cycloheximide series, and as compared with strain 52/152 produced about double the amount of fungicidin. This strain 52/152 was also insensitive to additions to the cultivation medium of fungicidin up to a concentration of 20,000 units/ml. In the strains studied, a direct proportionality was observed between fungicidin production and sensitivity to it. The interrelation of their production is discussed from the viewpoint of a common precursor for fungicidin and cycloheximide (malonyl-coenzyme A).


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