1887

Abstract

SUMMARY

The effects of different concentrations of (–) threo and (+) threo-chloramphenicol on the growth of have been studied. The results indicate: () both isomers caused an increase in the total population largely independent of concentration; () at concentrations between 100–200 g./ml. both isomers gave a secondary increase in growth after a secondary lag period of 4–6 days; () both isomers inhibited the growth rate at concentrations comparable with those which inhibit bacterial growth and protein synthesis. The (+) threo isomer was twice as effective as the (–) threo isomer, though it did not give any inhibition below 22 g./ml. () above 50 g./ml. the (–) threo isomer gave a significantly greater lag period than below this concentration. The (+) threo isomer did not affect the lag period below 25 g./ml., but above this concentration, an increase in the concentration lengthened the lag period at the same rate as with the (–) threo isomer above 50 g./ml.

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/content/journal/micro/10.1099/00221287-39-2-275
1965-05-01
2022-06-29
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