1887

Abstract

SUMMARY:

Over 100 histidine-dependent mutants were isolated from strain 655 of Paper chromatography was used to differentiate the mutants into classes according to their ability to accumulate Pauly-positive imidazoles. Classes and did not accumulate any detectable Pauly-positive imidazoles. Mutants of class accumulated -amino-1-ribosyl-4-imidazolecarboxamide, mutants of class accumulated imidazoleglycerol, and mutants of class accumulated imidazoleacetol. Mutants of class accumulated histidinol and were incapable of utilizing exogenous -histidinol. A comparison of the accumulations obtained from mutants of with accumulations obtained from previously characterized mutants of indicates that a similar, if not identical, pathway for the biosynthesis of -histidine is used by these two species.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-39-2-185
1965-05-01
2021-07-25
Loading full text...

Full text loading...

/deliver/fulltext/micro/39/2/mic-39-2-185.html?itemId=/content/journal/micro/10.1099/00221287-39-2-185&mimeType=html&fmt=ahah

References

  1. Ames B. B., Garry B., Herzenberg L. 1960; The genetic control of the enzymes of histidine biosynthesis in Salmonella typhimurium. J. gen. Microbiol 22:369
    [Google Scholar]
  2. Ames B. N., Hartman P. E. 1962; Genes, enzymes, and control mechanisms in histidine biosynthesis. In The Molecular Basis of Neoplasia322–45 Austin, Texas: University of Texas Press;
    [Google Scholar]
  3. Ames B. N., Martin R. G., Garry B. J. 1961; The first step of histidine biosynthesis. J. biol. Chem 236:2019
    [Google Scholar]
  4. Ames B. N., Mitchell H. K. 1952; The paper chromatography of imidazoles. J. Amer. chem. Soc 74:252
    [Google Scholar]
  5. Ames B. N., Mitchell H. K. 1955; The biosynthesis of histidine. Imidazoleglycerol phosphate, imidazoleacetolphosphate, and histidinol phosphate. J. biol. Chem 212:687
    [Google Scholar]
  6. Ames B. N., Mitchell H. K., Mitchell M. B. 1953; Some new naturally occurring imidazoles related to the biosynthesis of histidine. J. Amer. chem. Soc 75:1015
    [Google Scholar]
  7. Block R. J., Durrum E. L., Zweig G. 1958 A Manual of Paper Chromatography and Paper Electrophoresis110–69 New York: Academic Press Inc;
    [Google Scholar]
  8. Davis B. D. 1949; The isolation of biochemically deficient mutants of bacteria by means of penicillin. Proc. natn. Acad. SciU.S.A 41891
    [Google Scholar]
  9. Haas F., Mitchell M. B., Ames B. N., Mitchell H. K. 1952; A series of histidineless mutants of Neurospora crassa. Genetics 37:217
    [Google Scholar]
  10. Hartman P. E. 1956; Linked loci in the control of consecutive steps in the primary pathway of histidine synthesis in Salmonella typhimurium. Genetic Studies with Bacteria Publ. Carneg. Instn;61235
    [Google Scholar]
  11. Hartman P. E., Loper J. C., Serman D. 1960; Fine structure mapping by complete transduction between histidine-requiring Salmonella mutants. J. gen. Microbiol 22:323
    [Google Scholar]
  12. Kloos W. E., Pattee P. A. 1965; Transduction analysis of the histidine region in Staphylococcus aureus. J. gen. Microbiol 39:195
    [Google Scholar]
  13. Lederberg J. 1950; Isolation and characterization of biochemical mutants of bacteria. Meth. med. Res 3:5
    [Google Scholar]
  14. Lederberg J., Lederberg E. M. 1952; Replica plating and indirect selection of bacterial mutants. J. Bad 63:399
    [Google Scholar]
  15. Pattee P. A., Baldwin J. N. 1961; Transduction of resistance to chlortetracycline and novobiocin in Staphylococcus aureus. J. Bact 82:875
    [Google Scholar]
  16. Pattee P. A., Baldwin J. N. 1962; Transduction of resistance to some macrolide antibiotics in Staphylococcus aureus. J. Bact 84:1049
    [Google Scholar]
  17. Smith D. W. E., Ames B. N. 1964; Intermediates in the early steps of histidine biosynthesis. J. biol. Chem 239:1848
    [Google Scholar]
  18. Vogel H. J., Bonner D. M. 1956; Acetylornithinase of Escherichia coli; partial purification and some properties. J. biol. Chem 218:97
    [Google Scholar]
  19. Vogel H. J., Davis B. D., Mingioli E. S. 1951; l-Histidinol, a precursor of l-histidine in Escherichia coli. J. Amer. chem. Soc 73:1897
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-39-2-185
Loading
/content/journal/micro/10.1099/00221287-39-2-185
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error