Methionine inhibition of the phenotypic expression of reverse mutations in the fission yeast was investigated. This inhibition occurred solely with L-methionine, and not with a variety of other growth factors. The inhibitory effect on revertant expression did not apply to a number of reverse and forward mutations other than . Alteration of the adenine supply to organisms before and after mutagen treatment had no effect. Methionine was shown to have additional inhibitory effects on the leakiness of an mutant, on complementation between -1 mutants, and on the growth of certain strains in the presence of the analogue 6-methyl-aminopurine. It is suggested that S-adenosylmethionine may be implicated in these methionine effects.


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