Soluble antigens extracted from rabbit skin infected with vaccinia virus produced immunodiffusion patterns containing up to 17 lines. At least 5 of the components which produced lines were labile when heated at 60°. Soluble material obtained from purified vaccinia virus particles produced 8 precipitin lines and an additional virus component was detected with antiserum prepared against inactivated virus particles. Seven of the virus particle precipitin lines were identical with soluble antigen lines, but up to 10 of the soluble antigen lines did not appear to represent components of the virus particle. It is suggested that they represent specific substances (perhaps enzymes) required for virus replication but not incorporated into the virus.


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