Rutilantin A has been tested for antiviral activity This antibiotic had no demonstrable effect on the growth of poliomyelitis or influenza viruses, but it completely inhibited the multiplication of rabbitpox virus. It was effective against rabbitpox virus when added to tissue-cell cultures as late as 4 hr after infection. The lowest concentration of rutilantin that prevented the formation of infective rabbitpox virus didnot apparently affect the synthesis of viral DNA or soluble antigens. It is concluded that rutilantin inhibits a late stage of virus development. The toxicity of rutilantin for both cultured tissue cells and animals makes it unlikely to be of value in the treatment of virus disease.


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