1887

Abstract

Rutilantin A has been tested for antiviral activity This antibiotic had no demonstrable effect on the growth of poliomyelitis or influenza viruses, but it completely inhibited the multiplication of rabbitpox virus. It was effective against rabbitpox virus when added to tissue-cell cultures as late as 4 hr after infection. The lowest concentration of rutilantin that prevented the formation of infective rabbitpox virus didnot apparently affect the synthesis of viral DNA or soluble antigens. It is concluded that rutilantin inhibits a late stage of virus development. The toxicity of rutilantin for both cultured tissue cells and animals makes it unlikely to be of value in the treatment of virus disease.

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/content/journal/micro/10.1099/00221287-38-1-143
1965-01-01
2022-01-29
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References

  1. Appleyard G., Westwood J. C. N. 1964; The growth of rabbitpox virus in tissue culture.. J. gen. Microbiol. 37:3
    [Google Scholar]
  2. Asheshov I. N., Gordon J. J. 1961; Rutilantin: an antibiotic substance with antiphage activity.. Biochem. J. 81:101
    [Google Scholar]
  3. Asheshov I. N., Strelitz F., Hall E., Flon H. 1954; A survey of Actinomycetes for anti-phage activity.. Antibiot. Chemother. 4:380
    [Google Scholar]
  4. Cooper P. D. 1955; A method for producing plaques in agar suspensions of animal cells.. Virology 1:397
    [Google Scholar]
  5. Crowle A. J. 1958; A simplified micro double-diffusion agar precipitin technique. J.. Lab. clin. Med. 52:784
    [Google Scholar]
  6. Ollis W. D., Sutherland I. O. 1961; A new family of antibiotics.. In Recent Developments in the Chemistry of Natural Phenolic Compounds. Ed. by Ollis W. D. Oxford and London: Pergamon Press.;
    [Google Scholar]
  7. Randles W. J. 1960; Induced fluorescence with acridine orange, after osmium fixation.. Nature, Lond. 187:964
    [Google Scholar]
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