A disaccharide was isolated by partial hydrolysis from the group specific polysaccharide of a streptococcus strain carrying the group antigen F. The most probable structure of the substance is 3-0-β-d-gluco-pyranosyl--acetyl-d-galactosamine. The disaccharide was 300 times more active than cellobiose in the inhibition of the F/anti-F system. This denotes that it is a component of the determinant group of the group antigen. Two other serologically active oligosaccharides were isolated from the hydrolysate. Though their structure was not fully elucidated, evidence was obtained that a tetrasaccharide consisting of two molecules of the disaccharide is an important part of a determinant group of the F antigen.


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