Summary: High-frequency sonic oscillations destroyed the plaque-forming ability of actinophages. Among the 31 actinophage strains studied, the fraction of viral particles which survived an exposure for 1 min. to vibrations of 20 kcyc./sec. varied from 100 to 0·0002%. Coliphage T2hr+ was more susceptible to ultrasonic treatment than were some actinophages and was more resistant than other actinophages. In general, large actinophage particles were more sensitive to sonic treatment than small particles. A 60 W. 20 kcyc./sec. M.S.E. Ultrasonic Disintegrator destroyed actinophages more rapidly than a 50 W., 9 kcyc./sec. Raytheon Sonic Oscillator. Electron micrographs of actinophage MSP8 treated with sonic vibrations showed progressive disruption of the viral particles. Susceptibility to sonic inactivation gave an additional criterion for grouping actinophages.


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