SUMMARY: Mutants of resistant to oxytetracycline were produced and DNA prepared from them was then used for transforming a sensitive strain. DNA from a first-step mutant seemed to transmit a single genetic factor. On the other hand, bacteria, transformed with DNA from a second-step mutant, showed a trimodal distribution of resistance, suggesting that at least two factors were involved in the process. Transformation with DNA from clones belonging to the first and second peaks of the distribution showed that such clones transmitted a single genetic factor for oxytetracycline resistance, while DNA from clones of the third peak transformed sensitive bacteria in a way similar to that of the second step mutant. The results suggested that the two factors are linked and that they had a cumulative effect on drug resistance.


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