SUMMARY: Cytological changes in , associated with exposure to the antimicrobial agent thiobenzoate, were investigated with the electron microscope. After incubation of proliferating cells for 2--3 hr with the inhibitor, the nucleus displayed a lessened electron density. Following this, gaps appeared in the nuclear membrane and canaliculi emanated toward the periphery of the cell. Complete loss of cytoplasmic organization appeared to be the terminal event. These changes were shown to differ from those incurred during autolysis, induced either by substrate deprivation by washing, or by a combination of substrate deprivation and accumulation of metabolic products in an ageing culture.


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