SUMMARY: Mn depressed the rate and extent of multiplication of several virulent strains of group A beta-haemolytic streptococci , and caused a 6-12 hr increase in the lag phases of related avirulent strains. Several other cations did not exert such differential inhibitory effects. Ca overcame the inhibitory effects of Mn in both kinds of organism. In suspensions of virulent strains, Mn depressed both nucleic acid and protein syntheses below the control values, but only nucleic acid synthesis was depressed in avirulent-organism suspensions; protein synthesis was largely unaffected. The oxidation of glucose was depressed below control values by Mn to a much greater extent in virulent strains than in avirulent strains.


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