1887

Abstract

SUMMARY: Fourteen of twenty-one naturally occurring amino acids inhibited competitively the utilization of tryptophan for growth by an indole- or tryptophan-requiring strain of . At less than inhibitory ratios of amino acid to tryptophan, certain amino acids enhanced the growth of this mutant. Growth on indole was neither enhanced nor inhibited by amino acids other than tryptophan. The uptake of tryptophan from the medium was inhibited by phenylalanine. The effects of amino acid on the growth of this strain with tryptophan can be explained by an inhibition of tryptophan uptake from the medium.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-34-1-31
1964-01-01
2024-12-10
Loading full text...

Full text loading...

/deliver/fulltext/micro/34/1/mic-34-1-31.html?itemId=/content/journal/micro/10.1099/00221287-34-1-31&mimeType=html&fmt=ahah

References

  1. Beadle G. W., Tatum E. L. 1945; Neurospora II. Methods of producing and detecting mutations concerned with nutritional requirements. Amer. J. Bot 32:678
    [Google Scholar]
  2. Bergmann E. D., Sicher S., Volcani B. E. 1952; Sparing effects in the biosynthesis of the aromatic amino-acids in Escherichia coli . Biochim. biophys. Acta 9:220
    [Google Scholar]
  3. Bonner D., Tatum E. L., Beadle G. W. 1943; The genetic control of biochemical reactions in Neurospora: A mutant strain requiring isoleucine and valine. Arch. Biochem 3:71
    [Google Scholar]
  4. Brockman H. E. 1960; Inhibition analysis of aromatic amino acid-requiring mutants of Neurospora crassa. Dissertation, Florida State University, Tallahassee, Florida:
    [Google Scholar]
  5. Brockman H. E., DeBusk A. G. 1960; Relationships between sparing and inhibition in a tryptophan-deficient mutant of Neurospora crassa . Ass. Southeastern Biologists Bull 7:2
    [Google Scholar]
  6. Brockman H. E., DeBusk A. G., Wagner R. P. 1959; Mutant-associated antagonisms in Neurospora crassa . Arch. Biochem 84:455
    [Google Scholar]
  7. Cushing J. E., Schwartz M., Bennett R. 1949; Altered responses of Neurospora crassa to inhibiting concentrations of indole. J. Bact 58:433
    [Google Scholar]
  8. DeBusk A. G., Wagner R. P. 1953; p-Hydroxyphenylpyruvic acid function in Neurospora crassa . J. Amer. chem. Soc 75:5131
    [Google Scholar]
  9. Doermann A. H. 1944; A lysineless mutant of Neurospora and its inhibition by arginine. Arch. Biochem 5:373
    [Google Scholar]
  10. Fincham J. R. S. 1950; Mutant strains of Neurospora deficient in animating ability. J. biol. Chem 182:61
    [Google Scholar]
  11. Haas F., Mitchell M. B., Ames B. N., Mitchell H. K. 1952; A series of histidineless mutants of Neurospora crassa . Genetics 37:217
    [Google Scholar]
  12. Haddox C. H. 1952; The accumulation of α-phenylglycine by mutants of Neurospora crassa stimulated by phenylalanine and tyrosine. Proc. nat. Acad. Sci., Wash 38:482
    [Google Scholar]
  13. Haskins F. A., Mitchell H. K. 1949; Evidence for a tryptophan cycle in Neurospora . Proc. nat. Acad. Sci., Wash 35:500
    [Google Scholar]
  14. Lein J., Mitchell H. K., Houlahan M. B. 1948; A method for selection of biochemical mutants of Neurospora. Proc. nat. Acad. Sci., Wash 34:435
    [Google Scholar]
  15. Mathieson M. J., Catcheside D. G. 1955; Inhibition of histidine uptake in Neurospora crassa . J. gen. Microbiol 13:72
    [Google Scholar]
  16. Nason A., Kaplan N. O., Colowick S. P. 1951; Changes in enzymatic constitution in zinc-deficient Neurospora. J. biol. Chem 188:397
    [Google Scholar]
  17. Newmeyer D., Tatum E. L. 1953; Gene expression in Neurospora mutants requiring nicotinic acid or tryptophan. Amer. J. Bot 40:393
    [Google Scholar]
  18. Panicker R. K., Shanmugasundaram E. R. B., Acharya U. S. 1962; The effect of amino acid on the uptake and utilization of tryptophan and other precursors of nicotinic acid by Neurospora crassa . J. gen. Microbiol 28:409
    [Google Scholar]
  19. Shanmugasundaram E. R. B., Sarma P. S. 1954; Tryptophan utilization by Neurospora crassa and the influence of pure amino acids. Current Sci. India 23:224
    [Google Scholar]
  20. Soboren J., Nyc J. F. 1961; Amino acid interactions in Neurospora crassa . J. Bact 82:20
    [Google Scholar]
  21. Srb A. M. 1953; Shifts in heterocaryotic dominance relations effected by modifier genes in Neurospora. Genetics 38:694
    [Google Scholar]
  22. Teas H. J., Horowitz N. H., Fling M. 1948; Homoserine as a precursor of threonine and methionine in Neurospora. J. biol. Chem 172:651
    [Google Scholar]
  23. Woodward V. W., deZeeuw J. R., Srb A. M. 1954; The separation and isolation of particular biochemical mutants of Neurospora by differential germination of conidia, followed by filtration and selective plating. Proc. nat. Acad. Sci., Wash 40:192
    [Google Scholar]
/content/journal/micro/10.1099/00221287-34-1-31
Loading
/content/journal/micro/10.1099/00221287-34-1-31
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error