SUMMARY: The antiviral effects of chick and mouse interferons on chick and mouse cells were studied. In both systems a small amount of antiviral activity was found in the heterologous assays which varied from approximately 1 to 10 % of the homologous antiviral effect. A difference in the uptake of interferon by homologous and heterologous cells was observed which only partly explained the relative species specificity of the antiviral action of the two interferons. Destruction of interferon by supernatants from homologous or heterologous cultures could not be shown. The slopes of the dose response curves of mouse or chick interferon seemed to be significantly different and were independent of the two cell strains employed.
GiffordG. E.,
toyS. T.,
lindenmannJ.1963; Studies on vaccinia virus plaque formation and its inhibition by interferon. II. Dynamics of plaque formation by vaccinia virus in the presence of interferon.. Virology19294
LindenmannJ.,
GiffordG. E.1963a; Studies on vaccinia virus plaque formation and its inhibition by interferon. I. Dynamics of plaque formation by vaccinia virus.. Virology19283
LindenmannJ.,
GiffordG. E.1963b; Studies on vaccinia virus plaque formation and its inhibition by interferon. III. A simplified plaque inhibition assay of interferon.. Virology19302
PollikoffR.,
DonikianM. A.,
PadronA.,
LiuO. C.1962; Tissue specificity of interferon prepared in various tissue cultures.. Proc. Soc. exp. Biol., N.Y110232
SellersR. F.,
FitzpatrickM.1962; An assay of interferon produced in Rhesus monkey and calf kidney tissue cultures using bovine enterovirus M6 as challenge.. Brit. J. exp. Path43674