1887

Abstract

SUMMARY: The antiviral effects of chick and mouse interferons on chick and mouse cells were studied. In both systems a small amount of antiviral activity was found in the heterologous assays which varied from approximately 1 to 10 % of the homologous antiviral effect. A difference in the uptake of interferon by homologous and heterologous cells was observed which only partly explained the relative species specificity of the antiviral action of the two interferons. Destruction of interferon by supernatants from homologous or heterologous cultures could not be shown. The slopes of the dose response curves of mouse or chick interferon seemed to be significantly different and were independent of the two cell strains employed.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-33-3-437
1963-12-01
2021-07-31
Loading full text...

Full text loading...

/deliver/fulltext/micro/33/3/mic-33-3-437.html?itemId=/content/journal/micro/10.1099/00221287-33-3-437&mimeType=html&fmt=ahah

References

  1. Andrews R. D. 1961; Specificity of interferon.. Brit. med. J i1728
    [Google Scholar]
  2. Gifford G. E., toy S. T., lindenmann J. 1963; Studies on vaccinia virus plaque formation and its inhibition by interferon. II. Dynamics of plaque formation by vaccinia virus in the presence of interferon.. Virology 19294
    [Google Scholar]
  3. Isaacs A., Hitchcock G. 1960; Role of interferon in recovery from virus infections.. Lancet ii69
    [Google Scholar]
  4. Isaacs A., Westwood M. A. 1959a; Inhibition by interferon of the growth of vaccinia virus in the rabbit skin.. Lancet ii324
    [Google Scholar]
  5. Isaacs A., Westwood M. A. 1959b; Duration of protective action of interferon against infection with West Nile virus.. Nature, Lond 1841232
    [Google Scholar]
  6. Lindenmann J., Gifford G. E. 1963a; Studies on vaccinia virus plaque formation and its inhibition by interferon. I. Dynamics of plaque formation by vaccinia virus.. Virology 19283
    [Google Scholar]
  7. Lindenmann J., Gifford G. E. 1963b; Studies on vaccinia virus plaque formation and its inhibition by interferon. III. A simplified plaque inhibition assay of interferon.. Virology 19302
    [Google Scholar]
  8. Pollikoff R., Donikian M. A., Padron A., Liu O. C. 1962; Tissue specificity of interferon prepared in various tissue cultures.. Proc. Soc. exp. Biol., N.Y 110232
    [Google Scholar]
  9. Porterfield J. S. 1960; A simple plaque inhibition test for the study of arthropod-borne viruses.. Bull. Wld Hlth Org 22373
    [Google Scholar]
  10. Ruiz-Gomez J., Isaacs A. 1963; Interferon production by different viruses.. Virology 198
    [Google Scholar]
  11. Sellers R. F., Fitzpatrick M. 1962; An assay of interferon produced in Rhesus monkey and calf kidney tissue cultures using bovine enterovirus M6 as challenge.. Brit. J. exp. Path 43674
    [Google Scholar]
  12. Sutton R. N. P., Tyrrell D. A. J. 1961; Some observations on interferon prepared in tissue cultures.. Brit. J. exp. Path 4299
    [Google Scholar]
  13. Tyrrell D. A. J. 1959; Interferon produced by cultures of calf kidney cells.. Nature, Lond 184452
    [Google Scholar]
  14. Wagner R. R. 1961; Biological studies of interferon. I. Suppression of cellular infection with eastern equine encephalomyelitis virus.. Virology 13323
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-33-3-437
Loading
/content/journal/micro/10.1099/00221287-33-3-437
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error