1887

Abstract

SUMMARY: A strain of , which antagonized the growth of , was shown to produce at least two antibiotic substances. A liquid medium was developed for their production, and cultural and assay procedures were defined. The antibiotics appear to be distinct from previously described derivatives of the true fungi and were named Amodin A and Amodin B. Both are active against certain Grampositive and acid-fast organisms, but Amodin B has the wider antibiotic spectrum and is active against some Gram-negative organisms and strains of Amodin A was produced in surface and submerged cultures, but in better yield in the latter; it was extracted and prepared as a crude product. It appears to be a moderately heat-labile peptide; though non-toxic to mice it did not prolong their survival when infected with or at the dosage of antibiotic used. Amodin B appeared only in surface cultures and was mainly present in the mycelium, from which it was liberated by dilute acid. It is relatively heat-stable and not inactivated by proteolytic enzymes. Amodin A production appears to be linked with the conidial mode of sporulation and Amodin B with the perithecial mode.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-33-2-191
1963-11-01
2019-12-13
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-33-2-191
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error