SUMMARY: uses a wide variety of extracellular materials to accelerate the rate of morphogenesis. The stimulants of morphogenesis do not appear to exert their effect through the action of such factors as buffering, ionic strength, tonicity of the medium, or chelation.

Both glucose and histidine stimulate the rate of incorporation of amino acids into protein but at differing stages of development. Glucose stimulates throughout differentiation while histidine shows maximal stimulatory ability at preculmination (i.e. the stage just prior to complete fructification). The two compounds exhibit a mutual antagonism when added together.

It is concluded that glucose is probably acting as a primary energy source, whereas histidine is not acting in this manner or as a limiting amino acid for protein synthesis.


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