1887

Abstract

SUMMARY: The formation of catalase activity by an Arthrobacter strain -9 is dependent upon the addition of exogenous haemin, or the iron-containing growth factor ferrichrome. The iron-containing antibiotic ferrimycin A inhibited the synthesis of catalase in bacterial suspensions supplemented with ferrichrome, but did not measurably alter catalase formation in suspensions supplemented with haemin. This suggests that ferrichrome is necessary for haemin (catalase) synthesis, and that ferrimycin A acts by blocking this step. Cell-free extracts of were able to synthesize haemin when incubated with an oxidizable substrate, protoporphyrin IX and iron supplied as ferrichrome.

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1963-07-01
2021-08-01
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References

  1. Bickel H., Gaumann E., Keller-Schierlein W., Prelog V., Vischer E., Wett-stein A., Zahner H. 1960; Uber eisenhaltige Wachstumsfaktoren, die Sideramine, und ihre Antagonisten, die eisenhaltigen Antibiotika Sideromycine. Experientia 16:129
    [Google Scholar]
  2. Burnham B. F. 1962; Bacterial iron metabolism: investigations on the mechanism of ferrichrome function. Arch. Biochem. Biophys 97:329
    [Google Scholar]
  3. Burnham B. F., Neilands J. B. 1961; Studies on the metabolic function of the ferrichrome compounds. J. biol. Chem 236:554
    [Google Scholar]
  4. Emery T., Neilands J. B. 1959; The iron-binding centre of ferrichrome compounds. Nature, Lond 184:1632
    [Google Scholar]
  5. Greenberg J., Barker H. A. 1962; A ferrichrome-requiring Arthrobacter which decomposes puromycin aminonucleoside. J. Bact 83:1163
    [Google Scholar]
  6. Hesseltine C. W., Pidacks C., Whitehall A. R., Bohonos N., Hutchings B. L., Williams J. H. 1952; Coprogen, a new growth factor for coprophylic fungi. J. Amer. chem. Soc 74:1362
    [Google Scholar]
  7. Lascelles J. 1956a; The synthesis of porphyrins and bacteriochlorophyll by cell suspensions of Rhodopseudomonas spheroides . Biochem. J 62:78
    [Google Scholar]
  8. Lascelles J. 1956b; An assay of iron protoporphyrin based on the reduction of nitrate by a variant strain of Staphylococcus aureus; synthesis of iron protoporphyrin by suspensions of Rhodopseudomonas spheroides . J. gen. Microbiol 15:404
    [Google Scholar]
  9. Lochhead A. G., Burton M. O., Thexton R. H. 1952; A bacterial growth factor synthesized by a soil bacterium. Nature, Lond 170:282
    [Google Scholar]
  10. Neilands J. B. 1952; A crystalline organo-iron compound from the fungus. Ustilago sphaerogena. J. Amer. chem. Soc 74:4846
    [Google Scholar]
  11. Paul K. G. 1960; Heme compounds in enzyme catalysis. In The Enzymes 2nd ed., vol 3 ed. by Boyer P. D., Lardy H., Myrback K. New York: Academic Press;
    [Google Scholar]
  12. Weil-Malherbe H., Schade R. 1948; Studies on the liver catalase of normal and cancerous rats. Biochem. J 43:118
    [Google Scholar]
  13. ZÄhner H., Hütter R., Bachmann E. 1960; Zur Kenntnis der Sideromycinwirkung. Arch. f. Mikrobiol 36:325
    [Google Scholar]
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