1887

Abstract

SUMMARY

A mono-quaternary amine, cetyltrimethylammonium bromide (Cetrimide), and bisquaternary diamine, triclobisonium chloride (Triburon), were examined for their action on Cetrimide, at 30 μg./ ml. inhibited growth, but the organism was not inhibited by as much as 1–28 mg. Triburon/ml. Cetrimide at 20 μg./ml. inhibited citric acid accumulation. Triburon, at concentrations up to 160 μg./ml., increased the citric acid concentration, the maximum yield being at 40 μg. Triburon/ml.; at higher concentrations of Triburon there was an inhibition of citric acid production. The effect of Triburon was still perceptible in the presence of ferric ions. Cetrimide and Triburon brought about an initial increase in sterol concentration, followed by a decrease at higher concentrations of these compounds. The effects of these compounds on citric acid production by preformed mycelia were similar to the effect on cultures growing from spores.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-31-1-23
1963-04-01
2024-12-13
Loading full text...

Full text loading...

/deliver/fulltext/micro/31/1/mic-31-1-23.html?itemId=/content/journal/micro/10.1099/00221287-31-1-23&mimeType=html&fmt=ahah

References

  1. Bomstein R. A., Johnson M. J. 1952; The mechanism of formation of citrate and oxalate b. Aspergillus niger. J. Mol. Chem 198:143
    [Google Scholar]
  2. Chughtai I. D., Walker T. K. 1954; The mechanism of formation of organic acids by mould fungi. 6. The influence of cyanide o. Aspergillus niger. Biochem. J 56:484
    [Google Scholar]
  3. Perlman D., Dorrell W. W., Johnson M. J. 1946; The effect of metallic ions on the production of citric acid b. Aspergillus niger. Arch. Biochem 11:131
    [Google Scholar]
  4. Ramakrishnan C. V., Steel R., Lentz C. P. 1955; The mechanism of citric acid formation and accumulation i. Aspergillus niger. Arch. Biochem. Biophys 55:270
    [Google Scholar]
  5. Saffran M., Denstedt O. 1948; A rapid method for the determination of citric acid. J. biol. chem 175:849
    [Google Scholar]
  6. Schnitzer R. J., Grunberg E., DeLorenzo W. F. 1960; In vivo antistaphylococcal activity of bisquaternary diamines. Antibiotics Annual 1959-60:785
    [Google Scholar]
  7. Schnitzer R. J., Grunberg E., DeLorenzo W. F., Bagdon R. E. 1959; Triclo-bisonium chloride (Triburon), an antimicrobial with local activity in living host tissue. Antib. & Chemo 9:267
    [Google Scholar]
  8. Seifter S., Dayton S., Novic B., Muntwyler E. 1950; The estimation of glycogen with the anthrone reagent. Arch. Biochem 25:191
    [Google Scholar]
  9. Shu P., Johnson M. J. 1948; Citric acid production by submerged fermentation wit. Aspergillus niger. Industr. Engng Chem 40:1202
    [Google Scholar]
  10. Umbreit W. W., Burris R. H., Stauffer J. F. 1951 Manometric Methods and Tissue Metabolism Minneapolis: Burgess Publishing Co;
  11. Vahouny G. V., Mayer R. M., Roe J. H., Treadwell C. R. 1960; Determination of 3-β-hydroxy sterols with anthrone reagent. Arch. Biochem. Biophys 86:210
    [Google Scholar]
/content/journal/micro/10.1099/00221287-31-1-23
Loading
/content/journal/micro/10.1099/00221287-31-1-23
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error