Spectrum of Forward Mutants in the pyr-3 Region of Neurospora Free

Abstract

SUMMARY:

About 200 forward mutants of Neurospora obtained as suppressors of arg were studied. All fell in the region, and all appeared deficient in aspartic transcarbamylase (ATC) to various degrees: extreme deficiencies in ATC (-N alleles) resulted in pyrimidine-dependence as well as suppression of arg, while partial ATC deficiencies ( lleles) led only to suppression. Five different complementation groups were represented among the -N alleles studied. Evidence is presented which suggests that -N and lleles affect ATC via different mechanisms.

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/content/journal/micro/10.1099/00221287-30-2-327
1963-02-01
2024-03-29
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References

  1. Benzer S., Frekse E. 1958; Induction of specific mutations with 5-bromouracil. Proc. nat. Acad. Sci., Wash 44:112
    [Google Scholar]
  2. Davis R. H. 1960; An enzymatic difference among pyr-S mutants of Neurospora crassa. Proc. nat. Acad. Sci., Wash 46:677
    [Google Scholar]
  3. Davis R. H. 1961; Suppressor of pyrimidine-3 mutants of Neurospora and its relation to arginine synthesis. Science 134:470
    [Google Scholar]
  4. Davis R. H. 1962; Consequences of a suppressor gene effective with pyrimidine and proline mutants of Neurospora. Genetics 47:351
    [Google Scholar]
  5. Davis R. H., Woodward V. W. 1962; The relationship between gene suppression and aspartic transcarbamylase activity in pyr-S mutants of Neurospora. Genetics 47:1075
    [Google Scholar]
  6. Jacob F., Monod J. 1959; Gènes de structure et gènes de régulation dans la biosynthèse des protéines. CR. Acad. Sci., Paris 249:1282
    [Google Scholar]
  7. Lacy A. M., Bonner D. M. 1961; Complementation between alleles of the td locus in Neurospora crassa. Proc. nat. Acad. Sci., Wash 47:61
    [Google Scholar]
  8. Mitchell M. B., Mitchell H. K. 1956; Tests for non-allelism at the pyrimidine-3 locus of Neurospora. Genetics 41:319
    [Google Scholar]
  9. Reissig J. L. 1959; Forward and back-mutation at the pyr-S locus of Neurospora. Heredity 13:144
    [Google Scholar]
  10. Reissig J. L. 1960; Forward and back mutation in the pyr-S region of Neurospora. I. Mutations from arginine dependence to prototrophy. Genet. Res., Camb 1:356
    [Google Scholar]
  11. Reissig J. L. 1963; Induction of forward mutants in the pyr-S region of Neurospora. J. gen. Microbiol 30:317
    [Google Scholar]
  12. Ryan F. J., Beadle G. W., Tatum E. L. 1943; The tube method of measuring the growth rate of Neurospora. Amer. J. Bot 30:784
    [Google Scholar]
  13. de Serres F. J. 1956; Studies with purple adenine mutants in Neurospora crassa. I. Structural and functional complexity in the ad-3 region. Genetics 41:668
    [Google Scholar]
  14. de Serres F. J. 1960; Studies with purple adenine mutants in Neurospora crassa. IV. Lack of complementation between different ad-SA mutants in heterokaryons and pseudowild types. Genetics 45:555
    [Google Scholar]
  15. Suyama Y., Munkres K. D., Woodward V. W. 1959; Genetic analyses of the pyr-S locus of Neurospora crassa: the bearing of recombination and gene conversion upon intraallelic linearity. Genetica 30:293
    [Google Scholar]
  16. Woodward V. W. 1962; Complementation and recombination among pyr-S hetero-alleles of Neurospora crassa. Proc. nat. Acad. Sci., Wash 48:348
    [Google Scholar]
  17. Yanofsky C., St Lawrence P. 1960; Gene action. Annu. Rev. Microbiol 14:311
    [Google Scholar]
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