%0 Journal Article %A Pappenheimer, A. M. %A Miller, Pauline A. %A Yoneda, Masahiko %T Kinetics of Diphtheria Toxin Formation %D 1962 %J Microbiology, %V 28 %N 3 %P 531-539 %@ 1465-2080 %R https://doi.org/10.1099/00221287-28-3-531 %I Microbiology Society, %X SUMMARY: Studies on the kinetics of diphtheria toxin formation in iron-free culture media by variants of the PW no. 8 strain of Corynebacterium diphtheriae labelled with 14C-phenylalanine or 35S-methionine, showed that the toxin protein was synthesized de novo from amino acids by growing organisms. Release of toxin into the extracellular medium occurred without lysis of more than a minor proportion of the bacterial population. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-28-3-531