Antibacterial Activity, Penicillinase Stability and Inducing Ability of Different Penicillins Free

Abstract

SUMMARY: There are now at least three main types of antibacterial activity shown by different penicillins-the ordinary penicillin G type, the type shown by methicillin active against penicillinase-producing staphylococci and the ‘broad spectrum’ type of activity shown by α-aminobenzylpenicillin.

The inducing capacity of different penicillins can be measured by the concentration required for maximal or half maximal induction, which gives the Michaelis (induction) constant, or by the total amount of enzyme eventually produced. But either of these methods of determining inducing capacity may give misleading results with penicillins which may be easily hydrolysed during the induction process.

Of the penicillins used methicillin is by far the best inducer-but it is uncertain how much this is due to a true ‘inducing affinity’ and how much a result of its resistance to hydrolysis.

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1962-07-01
2024-03-29
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References

  1. Batchelor F. R., Cameron-Wood J., Chain E. B., Rolinson G. N. 1961; 6-Amino-penicillanic acid. V. 6-Aminopenicillanic acid as a substrate for penicillinase and an inducer of penicillinase formation. Proc. roy. Soc. B, 154:514
    [Google Scholar]
  2. Batchelor F. R., Doyle F. P., Nayler J. K., Rolinson G. N. 1959; Synthesis of penicillin: 6-aminopenicillanic acid in penicillin fermentation. Nature, Lond. 183:257
    [Google Scholar]
  3. Boxer G. E., Everett P. M. 1949; The colorimetric determination of benzyl penicillin. Analyt. Chem. 21:670
    [Google Scholar]
  4. Gilson Betty St C, Parker R. F. 1948; Staphylococcal penicillinase: characteristics of the enzyme and its distribution. J. Bact. 55:801
    [Google Scholar]
  5. Henry R. G., Housewright R. D. 1947; Studies on penicillinase. II. Manometric methods of assaying penicillinase and penicillin, kinetics of the penicillinase-reaction and the effects of inhibitors on penicillinase. J. biol. Chem. 167:559
    [Google Scholar]
  6. Knox R. 1960; A new penicillin (BRL 1241) active against penicillin-resistant staphylococci. Brit. med. J. 2:690
    [Google Scholar]
  7. Knox R. 1961; A survey of new penicillins. Nature, Lond. 192:492
    [Google Scholar]
  8. Knox R., Smith J. T. 1961; The nature of penicillin resistance in staphylococci. Lancet ii:520
    [Google Scholar]
  9. Pollock M. R. 1957; Activity and specificity of inducers of penicillinase production in Bacillus cereus, strain NRRL 569. Biochem. J. 66:419
    [Google Scholar]
  10. Rolinson G. N., Batchelor F. R., Butterworth D., Cameron-Wood J., Cole M., . Eustace G. C., Hart M. V., Richards M., Chain E. B. 1960; Formation of 6-Aminopenicillanic acid from penicillin by enzymic hydrolysis. Nature, Lond. 187:236
    [Google Scholar]
  11. Rolinson G. N., Stevens S. 1961; Microbiological studies on a new broad spectrum penicillin (‘Penbritin’). Brit. med. J. 2:191
    [Google Scholar]
  12. Rolinson G. N., Stevens S., Batchelor F. R., Cameron-Wood J., Chain E. B. 1960; Bacteriological studies on a new penicillin—BRL 1241. Lancet ii:564
    [Google Scholar]
  13. Steinman H. G. 1961a; A biochemical comparison of 6-aminopenicillanic acid, benzyl penicillin and 2,6-dimethoxyphenyl-penicillin. Proc. Soc. exp. Biol., N.Y. 106:227
    [Google Scholar]
  14. Steinman H. G. 1961b; Factors modifying induced formation of penicillinase in Staphylococcus aureus. J. Bact. 81:895
    [Google Scholar]
  15. Tarr H. A. 1958; Mechanical aids for the phage-typing of Staphylococcus aureus. Mon. Bull. Minist. Hlth Lab. Serv. 17:64
    [Google Scholar]
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