SUMMARY: The synthesis of aspartate carbamyl transferase (ureidosuccinic synthetase), of dihydroorotic dehydrogenase and of alkaline phosphatase by a uracil-requiring strain of , when the organisms were suspended in a minimal medium lacking uracil, was followed subsequent to infection of the cells with bacteriophage T2r+ or with ghosts of the bacteriophage particles. The results were compared with the synthesis of these enzymes in uninfected cells. Following infection, the formation of all three enzymes was halted. Supplementation of the medium with casein hydrolysate and tryptophan or with 0-01 M-Mg++ + 10-3 M-spermine did not prevent the inhibition caused by bacteriophage infection.


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