RT Journal Article SR Electronic(1) A1 Van Heyningen, W. E. A1 Miller, Pauline AllanYR 1961 T1 The Fixation of Tetanus Toxin by GanĒµlioside JF Microbiology, VO 24 IS 1 SP 107 OP 119 DO https://doi.org/10.1099/00221287-24-1-107 PB Microbiology Society, SN 1465-2080, AB SUMMARY: The fixation of tetanus toxin by brain ganglioside has been confirmed. A method has been developed for assaying the toxin-fixing capacity of ganglioside in the analytical ultracentrifuge. Under appropriate conditions ganglioside will fix many times its own weight of toxin. Ganglioside preparations from brain contain at least three gangliosides; at least two of these differ in their sialic acid contents and toxinfixing capacities. The sialic acid residues (and their free carboxyl groups) are essential for toxin-fixation. Tetanus toxin does not appear (so far) to bring about any change in the ganglioside molecule., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-24-1-107