1887

Abstract

SUMMARY: A soluble trypanosomal antigen occurs in the serum of rats infected with This ‘exoantigen’ is probably not a protein and is electrophoretic- ally a slow-moving component in the serum. The exoantigen which is also present on the surface as an agglutinogen appears to protect the trypanosomes against adverse environment, preserving their infectivity for long periods Rats and mice immunized with exoantigen are protected against infection with the homologous strain of Rabbits infected chronically with form antibodies to exoantigen. On disintegration of the trypanosomes, in addition to exoantigen, ‘bound’ antigens are released. In the natural disease exoantigens induce antibodies which may be concerned with protection against further infection.

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1960-12-01
2021-10-25
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References

  1. Desowitz R.S. 1956; Effect of antibody on the respiratory rate of Trypanosoma vivax . Nature; Lond.: 177132
    [Google Scholar]
  2. Desowitz R.S. 1959a; Studies on immunity and host parasite relationships. I. The immunological response of resistant and susceptible breeds of cattle to trypanosomal challenge. Ann. trop. Med. Parasit 53:293
    [Google Scholar]
  3. Desowitz R.S. 1959b; Paper electrophoresis of trypanosomal extracts. Nature; Lond.: 184986
    [Google Scholar]
  4. Duke H.L., Wallace J.M. 1930; ‘Red-cell adhesion’ in trypanosomiasis of man and animals. Parasitology 22:414
    [Google Scholar]
  5. Fromentin H. 1959; Trypanosomiase humaine accidentelle àTrypanosoma ganibiense. Considérations sur la souche infectante et sur la réponse de l’organisme. Bull. Soc. Path. exot 52:181
    [Google Scholar]
  6. Gray A.R. 1960; Precipitating antibody in trypanosomiasis of cattle and other animals. Nature; Lond.: 1861058
    [Google Scholar]
  7. Hughes D.E. 1951; A press for disrupting bacteria and other micro-organisms. Brit. J. exp. Path 32:97
    [Google Scholar]
  8. Inoki S., Kituana T., Nakabayasi T., Kurogochi H. 1952; Studies on the immunological variations in Trypanosoma gambiense . Med. J. Osaka University 3:357
    [Google Scholar]
  9. Kohn J. 1959; Small-scale and micro-membrane filter-electrophoresis and immunoelectrophoresis. The Protides of Biological Fluids. Proceedings 6th Colloquium Bruges, 1958 Amsterdam: Elsevier Publishing Company;74
    [Google Scholar]
  10. Marulli A. 1910; Azione esercitata dal siero e dal cavia tripanosomizzata sulla tripanosomiasi sperimentale. Boll. Soc. Ital. Med. Igiene colon p. 24 Reported in Sleeping Sickness Bur. Bull. 2:216
    [Google Scholar]
  11. Pantizel R., Lafaije A., Duret J. 1959; Diagnostic sérologique de la maladie du sommeil. I. Amélioration de l’antigène préparé à partir de Trypanosoma equiperdum . Bull. Soc. Path. exot 52:318
    [Google Scholar]
  12. Polge C., Soltys M.A. 1957; Preservation of trypanosomes in the frozen state. Trans. R. Soc. trop. Med. Hyg 51:519
    [Google Scholar]
  13. Rodhain J., Valckeg, Van Gidsenhoven G. 1941; Considérations sur le diagnostic et la thérapeutique de la méningo-encéphalite trypanosomique humaine d’après l’observation de quatre Européens atteints de la maladie du sommeil. Existence dans le sang et le liquide encéphalo-rachidien des malades sensibilisatrices fixant le complément. Ann. Soc. beige Med. trop 21:195
    [Google Scholar]
  14. Schochaers F., Neujean G., Evens F. 1953; Valeur pratique de la réaction de fixation du complément dans la maladie du sommeil à Trypanosoma ganibiense. I. LE diagnostic de la maladie. Ann. Soc. beige Med. trop 33:141
    [Google Scholar]
  15. Smithies O. 1955; Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. Biochem. J 61:629
    [Google Scholar]
  16. Soltys M.A. 1957; Immunity in trypanosomiasis. II. Agglutination reaction with African trypanosomes. Parasitology 47:390
    [Google Scholar]
  17. Thillet C.J. Jr. Chandler A.C. 1957; Immunization against Trypanosoma brucei in rats by injections of metabolic products. Science 125:346
    [Google Scholar]
  18. Thurston J. 1958; The effect of immune sera on the respiration of Trypanosoma brucei in vitro . Parasitology 48:463
    [Google Scholar]
  19. Wallace J.M., Wormall A. 1931; Red cell adhesion in trypanosomiasis of man and other animals. II. Some experiments on the mechanism of the reaction. Parasitology 23:346
    [Google Scholar]
  20. Weitz B. 1960; A soluble antigen of Trypanosoma brucei . Nature; Lond.: 185788
    [Google Scholar]
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