1887

Abstract

SUMMARY: When cultures of strain 15 were irradiated with ultraviolet radiation, the bacteria were induced to form a bactericidal material, colicin-15. Colicin-15 was released by the lysis of bacteria which underwent a residual growth without division. The only strains of bacteria sensitive to the action of colicin-15 were derivatives of strain 15. Three colicin-resistant strains were obtained, all of which became simultaneously sensitive to every T-phage, while the colicin-sensitive parental strains were lysed only by T2. By stepwise reversal of the phage sensitivity pattern, it was possible to revert colicin-resistant mutants to colicin sensitivity again. Only certain mutations conferring resistance in concert to phages T1, T3, T4, T5 and T7 seemed to result in colicin sensitivity. A model which will account for these phenomena is presented.

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1960-12-01
2024-04-20
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References

  1. Adams M.H. 1950; Methods of study of bacterial viruses. Methods in Medical Research 2: Yearbook Publishers, Inc., Chicago, U.S.A.
    [Google Scholar]
  2. Anderson E.H. 1944; Incidence of metabolic changes among virus-resistant mutants of a bacterial strain. Proc. nat. Acad. Sei., Wash 30:397
    [Google Scholar]
  3. Arber W., Kellenberger G. 1958; Study of the properties of seven defective- lysogenic strains derived from Escherichia coli K12 (λ). Virology 5:458
    [Google Scholar]
  4. Ben-Gurion R., Hertman I. 1958; Bacteriocin-like material produced by Pasteurella pestis . J. gen. Microbiol 19:289
    [Google Scholar]
  5. Dehaan P.G. 1954; Genetic recombination in Escherichia coli B II. The crossresistanee of E. coli B to the phages T3, T4, and T7. Genetica 27:300
    [Google Scholar]
  6. De Mars R.I. 1955; The production of phage-related materials when bacteriophage development is interrupted by proflavine. Virology 1:83
    [Google Scholar]
  7. Delbrück M. 1946; Bacterial viruses or bacteriophages. Biol. Rev 21:30
    [Google Scholar]
  8. Demerec M., Fano U. 1945; Bacteriophage-resistant mutants in Escherichia coli . Genetics 30:119
    [Google Scholar]
  9. Fastier L.B. 1949; An antibiotic substance produced by a member of the Shigella group. J. Immunol 62:399
    [Google Scholar]
  10. Fredericq P. 1946a; Sur la specificité des actions antibiotiques. Schweiz. Z. allg. Path 9:385
    [Google Scholar]
  11. Fredericq P. 1946b; Sur la pluralité des recepteurs d’antibiose de E. coli . C.R. Soc. Biol., Paris 140:1189
    [Google Scholar]
  12. Fredericq P. 1947; Recherche comparée des propriétés biochimiques et des proprieties antibiotiques dans le groupe Coli-Aerogenes. Bull. Soc. Chim. biol., Paris 29:358
    [Google Scholar]
  13. Fredericq P. 1948a; Production de substances antibiotiques par certaines souches de Shigella . C.R. Soc. Biol., Paris 142:399
    [Google Scholar]
  14. Fredericq P. 1948b; Antibiotiques reciproques chez les Enterobacteriaceae. Rev. belg. Path Suppl.4 19:1
    [Google Scholar]
  15. Fredericq P. 1949; Sur la résistance croisée entre colicine E et bacteriophage II. C.R. Soc. Biol., Paris 143:1011
    [Google Scholar]
  16. Fredericq P. 1952; Recherche des propriétés lysogenes et antibiotiques chez les Salmonella . C.R. Soc. Biol., Paris 146:298
    [Google Scholar]
  17. Fredericq P. 1954; Induction de la production de colicine par irradiation ultraviolette de souches colicinogenes d’Escherichia coli . C.R. Soc. Biol., Paris 148:1276
    [Google Scholar]
  18. Fredericq P. 1955; Induction de la production de colicine et de bacteriophages par irradiation ultraviolette de souches colicinogenes et lysogenes d’Escherichia coli . C.R. Soc. Biol., Paris 149:2028
    [Google Scholar]
  19. Fredericq P. 1957; Genetics of two different mechanisms of resistance to colicins. In CIBA Foundation Symposium on Drug Resistance in Micro-organisms . Boston: Little, Brown and Co.;
    [Google Scholar]
  20. Fredericq P. 1958; Colicins and colicinogenic factors. Symposia Soc. Exp.Biol 12:104
    [Google Scholar]
  21. Fredericq P., Betz-Bareau M. 1952; Recombinants génétiques de souches marquées par résistance aux colicines et aux bactériophages. Ann. Inst.Pasteur 83:283
    [Google Scholar]
  22. Fredericq P., Gratia A. 1950; Rapports entre colicines et bacteriophages du groupe T1-T7. Ant. v.Leeuwenhoek 16:119
    [Google Scholar]
  23. Furness G., Rowley D. 1957; The presence of the transmissible agent F in nonrecombining strains of Escherichia coli . J. gen. Microbiol 17:550
    [Google Scholar]
  24. Goebel W.F., Barry G.T., Shedlovsky T. 1956; Colicine K. I. The production of colicine K in media maintained at constant pH. J. exp. Med 10:3577
    [Google Scholar]
  25. Gratia A. 1925; Sur un remarquable exemple d’antagonism entre deux souches de Colibacille. C.R. Soc. Biol., Paris 93:1040
    [Google Scholar]
  26. Gratia A. 1932; Antagonism microbien et ‘Bactériophagie’. Ann. Inst. Pasteur 48:413
    [Google Scholar]
  27. Hamon Y. 1955; Étude d’une colicine elaboree par une culture de S. paratyphi B. Ann. Inst. Pasteur 88:193
    [Google Scholar]
  28. Hamon Y. 1956; Les bactériocines sont-elles des substances antigéniques? . C.R. Acad. Sci., Paris 242:1240
    [Google Scholar]
  29. Hamon Y., Lewe Z.V. 1955; Étude de l’induction par l’irradiation ultraviolette de quelques cultures d’E.coli K12 preablement rendues colicinogenes par transduction. Ann. Inst. Pasteur 89:336
    [Google Scholar]
  30. Hirota Y. 1956; Artificial elimination of the F-factor in Bacterium coli, K-12. Nature; Lond.: 17892
    [Google Scholar]
  31. Hirota Y. 1957; Acriflavine as an effective agent for eliminating F-factor in Escherichia coli K-12. Nature; Lond.: 180655
    [Google Scholar]
  32. Ivanovics G., Alföldi L. 1954; A new antibacterial principle: megacine. Nature; Lond.: 174465
    [Google Scholar]
  33. Ivanovics G., Alföldi L. 1955; Observations on lysogenesis in B. megaterium and on megacine, the antibacterial principle of this bacillus species. Acta microbiol. Acad. Sci., Hung 2:275
    [Google Scholar]
  34. Ivanovics G., Alföldi L. 1957; Bacteriocinogenesis in Bacillus megaterium . J. gen. Microbiol 16:522
    [Google Scholar]
  35. Ivanovics G., Alföldi L., Lovas B. 1957; Cultivation and electron microscopy of a bacteriocinogenic strain of Bacillus megaterium . Acta microbiol. Acad. Sci., Hung 4:295
    [Google Scholar]
  36. Ivanovics G., Nagy E. 1958; Hereditary aberrancy in growth of some Bacillus megaterium strains. J. gen. Microbiol 19:407
    [Google Scholar]
  37. Jacob F. 1954; Biosynthese induite et mode d’action d’une pyocine, antibiotique de Pseudomonas pyocyanea . Ann. Inst. Pasteur 86:149
    [Google Scholar]
  38. Jacob F., Lwoff A., Siminovitch L., Wollman E. 1953; Definition de quelques termes relatifs à la lysogènie. Ann. Inst.Pasteur 84:222
    [Google Scholar]
  39. Jacob F., Siminovitch L., Wollman E. 1952; Sur la biosynthese d’une colicine et sur son mode d’action. Ann. Inst. Pasteur 83:295
    [Google Scholar]
  40. Kellenberger G., Kellenberger E. 1956; iStude de souches colicinogenes au microscope electronique. Schweiz. Z. allg. Path 19:582
    [Google Scholar]
  41. Lederberg J. 1947; Gene recombination and linked segregations in Escherichia coli . Genetics 32:505
    [Google Scholar]
  42. Lieb M. 1951; Forward and reverse mutation in a histidine-requiring strain of Escherichia coli . Genetics 36:460
    [Google Scholar]
  43. Ludford C.G., Lederer M. 1953; The antibiotics of E. coli . Aust. J. exp. Biol. med. Sci 31:553
    [Google Scholar]
  44. Roepke R.R., Libby R.L., Small M.H. 1944; Mutation or variation of Escherichia coli with respect to growth requirements. J. Bact 48:401
    [Google Scholar]
  45. Ryan F.J. 1953; Natural selection in bacterial populations. Proc. Sixth Inter. Cangr. Microbiol 1:649
    [Google Scholar]
  46. Ryan F.J., Fried P., Mukai F. 1955; A colicin produced by cells that are sensitive to it. Biochim. biophys. Acta 18:131
    [Google Scholar]
  47. Ryan F.J., Schneider L.K. 1948; The consequences of mutation during the growth of biochemical mutants of Escherichia coli. I. The pattern of adaptation of histidineless cultures. J. Bact 56:699
    [Google Scholar]
  48. Ryan F.J., Schneider L.K. 1949; Mutations during the growth of biochemical mutants of Escherichia coli . Genetics 34:72
    [Google Scholar]
  49. Zamenhof S., Greer S. 1958; Heat as an agent producing high frequency of mutations and unstable genes in Escherichia coli . Nature; Lond.: 182611
    [Google Scholar]
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