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Abstract
SUMMARY: It has been shown that the alleles 5, 6 and 7 at the am locus in Neurospora crassa backmutate; the alleles 4, 8, 9 and 11 do not backmutate at detectable frequencies. Wild-types were recovered in low frequencies from crosses between different am alleles. It has been shown that each of the twelve am alleles, so far investigated, is unique with respect to at least one of the following criteria: mutation, recombination, complementation, type of glutamic dehydrogenase produced. It is argued that the minimum number of possible mutations at the am locus, which can affect glutamic dehydrogenase production, is eighteen. The probability that this minimum estimate is too large is less than 1 %.
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© Society for General Microbiology 1960