1887

Abstract

SUMMARY: A bacteriological study was made of blood specimens taken repeatedly during a 2-year period from a child with subacute bacterial endocarditis who received intensive treatment with antibiotics. The conventional bacillary form of sp. was present in the blood and bone marrow of the patient before the beginning of antibiotic therapy and on occasions when the administration of antibiotics was suspended. These were the periods when the patient showed overt symptoms of clinical illness. When antibiotic therapy was adequate to produce clinical remission of symptoms, the infecting organism was not eradicated, but persisted in the blood in a small granule-like form that could be demonstrated and cultured only by highly specialized techniques. The cultural procedures required to bring about reversion of the granule-like form to the conventional bacillary form and the morphology of the various transitional forms that the organism assumed during the reversion process are described and illustrated.

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/content/journal/micro/10.1099/00221287-23-2-315
1960-10-01
2024-12-07
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References

  1. Billings F., Rosenow E. C. 1913; The etiology and vaccine treatment of Hodgkin’s disease. J. Amer. med. Ass 61:2122
    [Google Scholar]
  2. Bunting C. H., Yates J. L. 1913a; Cultural results in Hodgkin’s disease. Arch. int. Med 12:236
    [Google Scholar]
  3. Bunting C. H., Yates J. L. 1913b; An etiologic study of Hodgkin’s disease. J. Amer. med. Ass 61:1803
    [Google Scholar]
  4. Carpenter C. M., Howard D. H., Lehman E. L. 1956; Preliminary characterization of a group of unidentified pleomorphic bacteria isolated from blood and other tissues. J. Lab. clin. Med 47:194
    [Google Scholar]
  5. Cunningham W. F. 1917; The status of diphtheroids with special reference to Hodgkin’s disease. Amer. J. med. Sci 153:406
    [Google Scholar]
  6. Dienes L. 1939; ‘L’ organisms of Klieneberger and Streptobadllus moniliformis . J. infect. Dis 65:24
    [Google Scholar]
  7. Dienes L. 1942; The significance of the large bodies and the development of L type of colonies in bacterial cultures. J. Bact 44:37
    [Google Scholar]
  8. Fitz-James P. C. 1958; Studies on the morphology and nucleic acid content of protoplasts of Bacillus megaterium. . J. Bact 75:369
    [Google Scholar]
  9. Fleisher M. S. 1952; Significance of diphtheroid micro-organisms in blood cultures from human beings. Amer. J. med. Sci 224:548
    [Google Scholar]
  10. Gilmore E., Burnett G. W. 1959; Isolation and maintenance of oral L forms of bacteria in liquid media. J. Bact 77:147
    [Google Scholar]
  11. Jiménez Díaz C., Arjona E. 1949; A new germ not described before, in subacute abacterial endocarditis (Corynebacterium endocarditis). . Bull. Inst. med. Res.,Madrid 2:71
    [Google Scholar]
  12. Kassel R. 1958; Etiological considerations in Hodgkin’s disease. Ann. N.Y. Acad. Sci 73:335
    [Google Scholar]
  13. Kassel R., Rottino A. 1955; Significance of diphtheroids in malignant disease studied by germ-free techniques. A.M.A. Arch. int. Med 96:804
    [Google Scholar]
  14. Klieneberger-Nobel E. 1949; Origin, development and significance of L-forms in bacterial cultures. J. gen. Microbiol 3:434
    [Google Scholar]
  15. Klieneberger-Nobel E. 1951; Filterable forms of bacteria. Bact. Rev 15:77
    [Google Scholar]
  16. Mcdermott W. 1958; Microbial persistence. Yale J. Biol. Med 30:257
    [Google Scholar]
  17. Nelson J. B. 1936; Studies on an uncomplicated coryza of the domestic fowl. VII. Cultivation of the coccobacilliform bodies in fertile eggs and in tissue cultures. J. exp. Med 64:749
    [Google Scholar]
  18. Pappenheimer A. M., Molloy E., Rose H. M. 1945; Presence of granules resembling elementary bodies in yolk cells of normal eggs. Proc. Soc. exp. Biol., N.Y 58:313
    [Google Scholar]
  19. Spiegelman S., Aronson A. I., Fitz-James P. C. 1958; Isolation and characterization of nuclear bodies from protoplasts of Bacillus megaterium . J. Bact 75:102
    [Google Scholar]
  20. Van Herick W., Eaton MD. 1945; An unidentified pleuropneumonia-like organism isolated during passages in chick embryos. J. Bact 50:47
    [Google Scholar]
  21. Warren J., Wittler R. G., Vincent M. 1955; Cultivation of tissues in small sealable dishes. J. Lab. clin. Med 46:144
    [Google Scholar]
  22. Wittler R. G. 1952; The L-form of Haemophilus pertussis in the mouse. J. gen. Microbiol 6:311
    [Google Scholar]
  23. Wittler R. G., Cary S. G., Lindberg R. B. 1956; Reversion of a pleuropneumonialike organism to a corynebacterium during tissue culture passage. J. gen. Microbiol 14:763
    [Google Scholar]
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