1887

Abstract

SUMMARY: Seven analogues of vitamin B were examined for their influence upon the growth of ATCC 4797 and 113–3. The analogues were active in promoting the growth of and but were essentially inactive for For three of the analogues were active and four inactive. In and in the ‘inactive’ analogues antagonized the growth- promoting action of cyanocobalamin, apparently by satinrating the cells’ mechanism for ‘binding’ the vitamin and so preventing its uptake.

Tests were also carried out with and on twelve derivatives of benziminazole. None of these proved inhibitory towards at least up to 100 g./ml. culture medium. Eight of the compounds were inhibitory towards ; the effects were relatively small, however, and were possibly unrelated to the metabolism of vitamin B.

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1959-12-01
2022-01-23
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