%0 Journal Article %A Ada, G. L. %A French, E. L. %T Stimulation of the Production of Neuraminidase in Vibrio cholerae Cultures by N-Acetylmannosamine %D 1959 %J Microbiology, %V 21 %N 3 %P 561-568 %@ 1465-2080 %R https://doi.org/10.1099/00221287-21-3-561 %I Microbiology Society, %X SUMMARY: Addition of N-acetylmannosamine to a basal culture medium inoculated with Vibrio cholerae strain 4Z stimulated the production of neuraminidase. N-Acetylglueosamine and N-acetylgalactosamine under similar circumstances were inactive. N-Acetylmannosamine, added to medium inoculated with V. cholerae, persisted for at least 12 hr; under similar conditions N-acetylglucosamine was rapidly metabolized. Both D-mannosamine HCl and D-glucosamine HCl resisted enzymic attack by 561V. cholerae. The former compound severely inhibited growth of the organisms; the latter had no such effect. These findings are discussed, particularly in their relationship to the discovery that N-acetylneuraminic acid, which is a condensation product between N-acetylmannosamine and pyruvate, also induces neuraminidase. %U https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-21-3-561