@article{mbs:/content/journal/micro/10.1099/00221287-21-1-30, author = "Watanabe, T. and Watanabe, M.", title = "Transduction of Streptomycin Sensitivity into Resistant Mutants of Salmonella typhimurium", journal= "Microbiology", year = "1959", volume = "21", number = "1", pages = "30-39", doi = "https://doi.org/10.1099/00221287-21-1-30", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-21-1-30", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "Summary: The infection of slow-growing one-step intermediate streptomycin- resistant mutants with phage from wild-type bacteria, indifferent (one-step completely resistant) or other one-step intermediate resistant mutants gives rise to fastgrowing streptomycin-sensitive transductants. From this fact it is clear that both slow growth and streptomycin resistance are controlled by a single locus. The transductants are very easily detected on the poor background growth of the intermediate resistant recipient. With this technique it has become possible to cross one-step resistance with resistance, indifference and sensitivity. The results so far obtained indicate that one-step intermediate resistance is controlled by multiple loci. None of these loci is linked to the indifference locus. The fast-growing mutants which develop from the two-step resistant mutants are assumed from the transduction analysis to be due to reverse mutations at the first step loci.", }