1887

Abstract

SUMMARY: Two protozoa, and , were used to study the mode of action and side effects of three antihistamines: diphenhydramine, tripelennamine and pheniramine. The mode of action was studied by inhibition analysis and the side effects by motility tests. The use of these methods as preliminary screening procedures for new chemotherapeutic agents is discussed.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-21-1-264
1959-08-01
2024-12-05
Loading full text...

Full text loading...

/deliver/fulltext/micro/21/1/mic-21-1-264.html?itemId=/content/journal/micro/10.1099/00221287-21-1-264&mimeType=html&fmt=ahah

References

  1. Carlisle E. M., Crescitelli F. 1950; Selective inhibition of brain respiration by Benadryl. Science 112:272
    [Google Scholar]
  2. Crescitelli F., Geissman T. A. 1951; Certain effects of antihistamines and related compounds on frog nerve fibers. Amer. J. Physiol 164:509
    [Google Scholar]
  3. Hutner S. H., Baker H., Aaronson S., Nathan H. A., Rodriquez E., Lockwood S., Sanders M., Peterson R. A. 1957; Growing Ochromonas malhamensis above 35° C. J. Protozool 4:259
    [Google Scholar]
  4. Jahn T. L., Danforth W. 1952; Inhibition of growth of a green flagellate by the antihistamine Benadryl. Proc. Soc. exp. Biol., N.Y 80:13
    [Google Scholar]
  5. Kudo R. R. 1950 Protozoology Philadelphia: C. C. Thomas;
    [Google Scholar]
  6. Landis L., Krops S. 1951; Influence of histamine upon the fungistatic action of antihistamines. Proc. Soc. exp. Biol., N.Y 76:538
    [Google Scholar]
  7. Nathan H. A., Funk H. B. 1959; Relationship between pteridines and other heterocycles (Purines, riboflavin, and vitamin B12). Amer. J. Clin. Nutr in the Press
    [Google Scholar]
  8. Reiss F., Caroline L. 1955; Studies with B. dermitidis growth inhibitors. A.M.A. Arch. Derm 71:500
    [Google Scholar]
  9. di Ritis F., Zanussi C. 1949; Attivita antimicrobica di un anti-istaminico sintetico (N-dimetilaminoetil-N-benzilanilina). Riv. 1st Sieroter. ital 24:10
    [Google Scholar]
  10. Schayer R. W. 1956; The origin and fate of histamine in the body. Histamine London: J. and A. Churchill Ltd;
    [Google Scholar]
  11. Steffen C. G., Zimmerman M., Mihan R. 1956; Diphenhydramine hydrochloride as a local anesthetic agent. A.M.A. Arch. Derm 74:76
    [Google Scholar]
  12. Stokstad E. L. R., Seaman G. R., Davis R. J., Hutner S. H. 1956; Assay of thioctic acid. Meth. Biochem. Anal 3:23
    [Google Scholar]
/content/journal/micro/10.1099/00221287-21-1-264
Loading
/content/journal/micro/10.1099/00221287-21-1-264
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error