SUMMARY: Five mutants of which grow to a greater or less extent when the minimal medium is supplemented with vitamin B have been studied. They fall into two groups according to the further effect of serine + glycine on growth. (1) Two strains showed full and rapid growth with pyridoxine alone and serine + glycine neither replaced this vitamin nor enhanced growth in its presence. (2) Three strains showed delayed and suboptimal growth with pyridoxine alone. With these serine + glycine had two effects: () it decreased the lag and enhanced the final extent of growth when added with pyridoxine; () it permitted suboptimal growth in the absence of pyridoxine. The second effect was dependent on (two strains), or greatly increased by (one strain), the concurrent addition of glycolaldehyde.


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