1887

Abstract

SUMMARY: The fixation of tetanus toxin by the receptor in nervous tissue is highly specific in so far as tetanus toxic protein (and toxoid to a much smaller extent), and apparently nothing else, is adsorbed from solutions of ionic strength greater than 0·15. At lower ionic strengths certain other proteins may be adsorbed by a mechanism that is probably different. The specific adsorption of toxic protein has been used as the basis of a chemical method of assay of the receptor which depends on the estimation of the amount of protein adsorbed under prescribed conditions by the unknown amount of receptor from a fixed amount of crude tetanus toxin.

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/content/journal/micro/10.1099/00221287-20-2-301
1959-04-01
2024-04-19
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References

  1. Fildes P. 1929; Medical Research Council. A System of Bacteriology in Relation to Medicine 3298 London: H.M. Stationery Office;
    [Google Scholar]
  2. Fulthorpe A. J. 1956; Adsorption of tetanus toxin by brain tissue. J. Hyg., Camb 54:315
    [Google Scholar]
  3. Lemétayer E., Nicol L., Girard D., Corvazier R., Cheyroux M. 1950; Recherches expérimentales sur les interactions du serum, l’anatoxine, de la toxine spécifique et des tissus dans le traitement prevéntif et curatif de l’intoxication tétanique. Ann. Inst. Pasteur 79:672
    [Google Scholar]
  4. Lemétayer E., Raynaud M., Nicol L., Turpin A. 1954; Action préventive spécifique précoce de l’anatoxine tétanique employée à doses massives. Ann. Inst. Pasteur 87:1
    [Google Scholar]
  5. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. 1951; Protein measurement with the Folin phenol reagent. J. biol. Chem 193:265
    [Google Scholar]
  6. Pillemer L., Wittler R. G., Burrell J. I., Grossberg D. B. 1948; The immunochemistry of toxins and toxoids. VI. Crystallization and characterization of tetanal toxin. J. exp. Med 88:205
    [Google Scholar]
  7. Pons L. 1938; L’anatoxine tétanique est-elle une toxine ayant perdu son pouvoir de fixation sur le système nerveux?. C.R. Soc. Biol., Paris 129:209
    [Google Scholar]
  8. Raynaud M., Lemétayer E., Turpin A., Nicol L., Rouyer M. 1951; Installation rapide d’un état de resistance a l’intoxication tétanique expérimentale par l’influence de doses massives d’anatoxine tetanique. C.R. Acad. Sci., Paris 233:586
    [Google Scholar]
  9. Raynaud M., Wright E. A. 1953; Rapid specific preventive action of tetanus toxoid. Nature; Lond: 171797
    [Google Scholar]
  10. van Heyningen W. E. 1959; The fixation of tetanus toxin by nervous tissue. J. gen. Microbiol 20:291
    [Google Scholar]
  11. Wassermann A., Takaki T. 1898; Über tetanusantitoxische Eigenschaften des normalen Centralnervensystems. Berl. klin. Wschr 35:5
    [Google Scholar]
  12. Wolters K. L., Fischoeder E. 1954; #x00DC;ber die Bindung von Tetanustoxin an Himsubstanz ohne und nach Vorbehandlung mit Tetanustoxoid. Z. Hyg. InfektKr 139:541
    [Google Scholar]
  13. Wright G. P. 1955; The neurotoxins of Clostridium botulinum and Clostridium tetani. Pharmacol. Rev 7:413
    [Google Scholar]
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