1887

Abstract

SUMMARY: The fixation of tetanus toxin by nervous tissue (Wassermann-Takaki phenomenon, 1898) has been re-investigated. Fixation is greatly dependent on the concentration of toxin and of receptor. Toxin is fixed in preference to toxoid, but its toxicity does not appear to be markedly diminished by fixation. A biological assay of the toxin receptor in nervous tissue and its components has been devised. The receptor activity is not due to a cerebroside, as thought by Landsteiner & Botteri (1906), but to some substance (present mainly in grey matter) that tends to associate with it.

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/content/journal/micro/10.1099/00221287-20-2-291
1959-04-01
2021-08-04
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References

  1. Bbooks V. B., Curtis D. R., Eccles J. C. 1955; The mode of action of tetanus toxin. Nature; Lond: 175120
    [Google Scholar]
  2. Carter H. E., Fujino Y. 1956; Biochemistry of the sphingolipides. IX. Configuration of cerebrosides. J. biol. Chem 221:879
    [Google Scholar]
  3. Coleman G. E. 1924; Action of leucocytes and of brain tissue on toxin of B. botulinus . J. infect. Dis 34:614
    [Google Scholar]
  4. Drury A. N., Miles J. A. R., Platt A. E., Plaut G., Weil H. 1936; Observations relating to psychosine sulphate: Its action upon bacteria, toxins, serum and red blood cells. J. Path. Bact 42:363
    [Google Scholar]
  5. Fulthorpe A. J. 1956; Adsorption of tetanus toxin by brain tissue. J. Hyg., Camb 54:315
    [Google Scholar]
  6. Klenk E., Leupold F. 1944; Über eine vereinfachte Methode zur Darstellung von phosphorfreien Cerebrosiden und über die als Spaltprodukte auftretenden Fettsäuren. 18. Mitteilung über Cerebroside. Z. physiol. Chem 281:208
    [Google Scholar]
  7. Landsteiner K., Botteri A. 1906; Über Verbindungen von Tetanustoxin mit Lipoiden. IV. Zbl. Bakt Orig 42:562
    [Google Scholar]
  8. Loening H., Thierfelder H. 1910; Über das Cerebron. IV. Mitteilung. Z. physiol. Chem 68:464
    [Google Scholar]
  9. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. 1951; Protein measurement with the Folin phenol reagent. J. biol. Chem 193:265
    [Google Scholar]
  10. Metchnikoff E. 1898; Recherches sur l’influence de l’organisme sur les toxines. Ann. Inst. Pasteur 12:81
    [Google Scholar]
  11. Pillemer L., Wittler R. G., Burrell J. I., Grossberg D. B. 1948; The immunochemistry of toxins and toxoids. VI. Crystallization and characterization of tetanal toxin. J. exp. Med 88:205
    [Google Scholar]
  12. Pons R. 1938; L’anatoxine tétanique est-elle une toxine ayant perdu son pouvoir de fixation sur le système nerveux?. C. R. Soc. Biol., Paris 129:209
    [Google Scholar]
  13. Takaki T. 1908; Über Tetanusgift bindende Bestandteile des Gehirns. Beitr. chem. Physiol. Path 11:288
    [Google Scholar]
  14. van Heyningen W. E. 1959; Chemical assay of the tetanus toxin receptor in nervous tissue. J. gen. Microbiol 20:301
    [Google Scholar]
  15. Wassermann A., Takaki T. 1898; Über tetanusantitoxische Eigenschaften des normalen Centralnervensystems. Berl. klin. Wschr 35:5
    [Google Scholar]
  16. Wright G. P. 1955; The neurotoxins of Clostridium botulinum and Clostridium tetani . Pharmacol. Rev 7:413
    [Google Scholar]
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