1887

Microbiology Society logo

Volume 2, Issue 2

The Inhibition of var. by Musarin, an Antibiotic produced by Meredith’s Actinomycete Free

Abstract

SUMMARY: Under selected conditions Meredith’s actinomycete produced culture fluids toxic to many fungi. From these fluids the active principle, called musarin, has been isolated by two methods. Preparations active in concentrations of 1/80,000-1/100,000 seemed substantially pure.

Musarin is an optically active acid of high molecular weight having by microtitration an equivalent weight of at least 4000. Analyses of the best preparations are in good agreement with an empirical formula (CHON). No definite conclusion can be drawn about the exact chemical nature of musarin; a protein-like structure seems to be excluded by the low nitrogen content, which recalls that of many bacterial polysaccharides; but formulation as a polysaccharide seems equally unsatisfactory because of the low oxygen content.

Tests indicate that musarin is one of the most potent antifungal antibiotics, though as an antibacterial agent it is less effective. It is active against several important plant parasites and it may be useful in combating the Panama disease of the banana plant and other fungal diseases of economic importance.

  • Received:
  • Published Online:
© Society for Gerenal Microbiology, 1948
Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-2-2-111
1948-05-01
2024-09-15
Loading full text...

Full text loading...

/deliver/fulltext/micro/2/2/mic-2-2-111.html?itemId=/content/journal/micro/10.1099/00221287-2-2-111&mimeType=html&fmt=ahah

References

  1. Catch J. R., Cook A. H., Kitchener J. A. 1945; Apparatus for micro-titrations with a glass electrode. J. chem. Soc p. 319:
     [Google Scholar]
  2. Foster J. W., Woodruff H. B. 1943; Quantitative estimation of streptothricin. J. Bact 45:408
     [Google Scholar]
  3. Le Page G. A., Campbell E. 1946; .Preparation of streptomycin. J. biol. Chem 162:163
     [Google Scholar]
  4. Meredith C. H. 1943; The antagonism of actinomyces to Fusariumoxysporumcubense.. Phytopath 33:403
     [Google Scholar]
  5. Meredith C. H. 1944; The antagonism of soil organisms to Fusariumoxysporumcubense. Phytopath 34:426
     [Google Scholar]
  6. Peck R. L., Walti A., Grater R. P., Flynn E., Hoffhine C. E., Allfrey V., Folkers K. 1946; Streptomyces antibiotics. VI. Isolation of streptothricin. J. Amer. chem. Soc 68:772
     [Google Scholar]
  7. Schatz A., Bugie E., Waksman S. A. 1944; .Streptomycin, a substance exhibiting antibiotic activity against Gram-positive and Gram-negative bacteria. Proc. Soc. exp. Biol., N.Y 55:66
     [Google Scholar]
  8. Thaysen A. C., Butlin K. R. 1945; Inhibition of the development of Fusariumoxysporumcubense by a growth substance produced by Meredith’s actinomycete. Nature,; Lond.: 156781
     [Google Scholar]
  9. Thaysen A. C., Morris M. 1947; .Medium suitable for the cultivation of Meredith’s actinomycete. Nature,; Lond.: 159100
     [Google Scholar]
  10. Waksman S. A. 1943; Production and activity of streptomycin. J. Bact 46:299
     [Google Scholar]
/content/journal/micro/10.1099/00221287-2-2-111
Loading
The Inhibition of Fusarium oxysporum var. cubense by Musarin, an Antibiotic produced by Meredith’s Actinomycete
Microbiology 2, 111 (1948); https://doi.org/10.1099/00221287-2-2-111
/content/journal/micro/10.1099/00221287-2-2-111
/content/journal/micro/10.1099/00221287-2-2-111
Loading

Data & Media loading...

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error