SUMMARY: Following the original inoculation of cotton rats with material from the spleen of a golden hamster containing Leishman-Donovan bodies, a number of serial passages were subsequently carried out in these animals. The parasite became rapidly adapted to the new host and a progressive infection resulted comparable with that in the golden hamster. Whereas death in the latter animal is the invariable sequel of infection, the cotton rat appears to be unaffected by the disease. The cotton rat thus provides a new and easily obtainable host for the study of experimental leishmaniasis in this country, including the chemotherapy of the disease.


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