Cysteamine and certain closely related derivatives induced lysis in a majority of 28 strains of ; cultures of all other genera tested were resistant. Forty-three additional sulphur and/or nitrogen containing compounds were unable to induce lysis. Optimum conditions for cysteamine activity included exposure of metabolizing post-log. phase organisms contained in shallow shaken layers of nutrient broth to the compound for 4-8 hr. Upon the completion of lysis, no formed cellular elements were visible by microscopy except flagella. The induction by cysteamine of a lysogenic bacteriophage or of an unusually large amount of an autolytic enzyme was not demonstrated.


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