Placing live or inactivated vesicular stomatitis virus of one serotype on chick cells in tissue culture prevented most of the cells from releasing infective virus of the other serotype when super-infected with it (heterotypic exclusion). Inactivated virus did not prevent super-infection with the same serotype and had no effect on the latent period or rate of virus release (homotypic non-exclusion and non-interference). The ‘Indiana’ serotype was more effective as heterotypic excluding agent than was the ‘New Jersey’ serotype, and exclusion was noticeable when only 12 min. elapsed between interfering and challenge virus. Each cell liberated virus of only one serotype when infected with live virus of both serotypes, but the serotype released was often (20–40%) not that of the particle first adsorbed. Heterotypic exclusion in fact behaved as if it were reversible and dependent on the multiplicities of infection, at least within the latent period. Many inactivated particles per cell were adsorbed before heterotypic exclusion was achieved.


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