1887

Abstract

Summary: Growth-inhibitory concentrations of chloramphenicol caused a prompt inhibition of protein synthesis in strain B. This inhibition was accompanied by alteration in nucleic acid synthesis from a logarithmic to a linear rate, and by the excretion into the medium of free purine and pyrimidine bases, three of which were identified as guanine, hypoxanthine and uracil. At slightly lower concentrations the antibiotic caused a slight stimulation of nucleic acid synthesis.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-18-3-767
1958-06-01
2024-12-08
Loading full text...

Full text loading...

/deliver/fulltext/micro/18/3/mic-18-3-767.html?itemId=/content/journal/micro/10.1099/00221287-18-3-767&mimeType=html&fmt=ahah

References

  1. Abelson P.H., Bolton E.T., Aldous E. 1952; The utilization of carbon dioxide in the synthesis of protein by Escherichia coli. . J. biol. Chem 198:165
    [Google Scholar]
  2. Britten R. 1954; Extracellular metabolic products of Escherichia coli during rapid growth. Science 119:578
    [Google Scholar]
  3. Dunlop S.G. 1949; The synthesis of amino acids by Escherichia coli in pure cultures. J. Bact 58:457
    [Google Scholar]
  4. Gale E.F. 1945; Studies on bacterial amino acid decarboxylases. Biochem. J 39:45
    [Google Scholar]
  5. Gale E.F., Folkes J.P. 1953a; The assimilation of amino acids by bacteria.14. Nucleic acid and protein synthesis in Staphylococcus aureus. . Biochem. J 53:483
    [Google Scholar]
  6. Gale E. F., Folkes J. P. 1953b; The assimilation of amino acids by bacteria.15. Actions of antibiotics on nucleic acid and protein synthesis in Staphylococcus aureus. . Biochem. J 53493
    [Google Scholar]
  7. Gale E.F., Folkes J. P. 1954; Effects of nucleic acids on protein synthesis and amino acid incorporation in disrupted staphylococcal cells. Nature; Lond.: 1731223
    [Google Scholar]
  8. Harrington M.G. 1954 Ph.D. Thesis National University of Ireland.:
  9. Haurowitz F. 1950 Chemistry and Biology of Proteins, 2nd ed.. New York: Academic Press;
    [Google Scholar]
  10. Markham R., Smith J.D. 1949; A technique for the identification and estimation of purine and pyrimidine bases, nucleosides and related substances. Biochem. J 45:294
    [Google Scholar]
  11. Partridge S.M., Brimley R.C. 1952; Displacement chromatography on synthetic ion exchange resins. 8. A systematic method for the separation of amino acids. Biochem. J 51:628
    [Google Scholar]
  12. Wisseman C.L., Smadel J.E., Hahn F.E., Hopps H.E. 1954; The mode of action of chloramphenicol. 1. Action of chloramphenicol on the assimilation of ammonia and on the synthesis of protein and nucleic acid in Escherichia coli. . J. Bact 67:662
    [Google Scholar]
/content/journal/micro/10.1099/00221287-18-3-767
Loading
/content/journal/micro/10.1099/00221287-18-3-767
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error